Research progress in influences of epigenetic modifications on PD-L1 expression in tumors / 国际肿瘤学杂志
Journal of International Oncology
; (12): 345-348, 2022.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-954287
Responsible library:
WPRO
ABSTRACT
Tumor cells expression of programmed death ligand-1 (PD-L1) is a major mechanism of immune escape and a predictor of therapeutic efficacy of immune checkpoint inhibitors. The expression of PD-L1 is regulated by a variety of mechanisms, among which epigenetic modifications such as DNA methylation, histone modification and non-coding RNA can promote the occurrence, development and drug resistance of tumors by regulating the expression of PD-L1. To clarify its regulation mechanism can bring new ideas for clinical immunotherapy of tumors.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2022
Document type:
Article