Mechanism of PI3K pathway in tumor immune microenvironment / 国际肿瘤学杂志

ABSTRACT

Immunosuppressive tumor microenvironment is one of the important factors affecting the efficacy of immune checkpoint inhibitors. The phosphatidylinositol 3-kinase (PI3K) -related signaling pathway is an important pathway involved in the occurrence and development of tumors, and the abnormal activation of this pathway is inextricably linked with the immunosuppressive tumor microenvironment. In-depth discussion of the mechanism of PI3K-related pathways in the tumor microenvironment can provide certain directions and ideas for improving the efficacy of immunotherapy, and explore the potential of immunotherapy.