Efficacy of conformal intensity-modulated radiotherapy with paclitaxel liposome versus cisplatin in the treatment of locally advanced cervical cancer / 中国基层医药

ABSTRACT

Objective:To investigate the efficacy of conformal intensity-modulated radiotherapy combined with paclitaxel liposome versus cisplatin in the treatment of locally advanced cervical cancer. Methods:Sixty patients with cervical cancer who received treatment in Rushan People's Hospital from February 2014 to September 2016 were included in this study. They were randomly assigned to undergo either conformal intensity-modulated radiotherapy combined with cisplatin (control group, n = 30) or conformal intensity-modulated radiotherapy combined with paclitaxel liposome (observation group, n = 30) for five cycles. Clinical efficacy and incidence of adverse reactions were compared between the two groups. Results:Total response rate in the observation group was slightly, but not significantly, higher than that in the control group [93.3% (28/30) vs. 90.0% (27/30), P > 0.05]. The incidences of myelosuppression and gastrointestinal reactions in the observation group were 26.7% (8/30) and 53.3% (16/30), respectively, which were significantly lower than those in the control group [46.7% (14/30), 76.7% (23/30), χ2 = 5.16, 7.17, both P < 0.05]. After radiotherapy and chemotherapy, the score of quality of life in the observation group was significantly higher than that in the control group ( t = 3.19, 4.12, 3.22, 4.53, 3.63, 3.08, 3.78, all P < 0.05). Conclusion:Conformal intensity-modulated radiotherapy combined with paclitaxel liposome for treatment of locally advanced cervical cancer can effectively reduce myelosuppression and gastrointestinal reactions and improve quality of life. Conformal intensity-modulated radiotherapy combined with paclitaxel liposome has certain clinical significance in the treatment of locally advanced cervical cancer.