Fetal programming: research status and reversal of intergenerational obesity caused by maternal obesity / 中华内分泌代谢杂志

ABSTRACT

Fetal programming refers to as the process that organ structures and related functions undergo programming at the embryo and fetus phase. Any stimulus and injuries during embryo and fetal development can lead to changes in multiple fetal organs. Among them, maternal obesity is an important factor. This work reviews the data from recent animal models and human regarding the effects of maternal obesity on fetal programming, with a particular focus on the mechanisms and reversal strategies.