Prevalence of occult HBV infection in alcholic and non-alcoholic subjects lacking the hepatitis B surface antigen / 대한내과학회지
Korean Journal of Medicine
; : 539-545, 2008.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-9626
Responsible library:
WPRO
ABSTRACT
BACKGROUNDS/AIMS:
Hepatitis B virus (HBV) infection and chronic alcoholism are major risk factors for chronic liver disease in Korea.METHODS:
We investigated the prevalence of occult HBV infection in 198 non-alcoholic (group I) and 85 chronic alcoholic subjects (group II), none of whom showed the hepatitis B surface antigen (HBsAg). Among chronic alcoholics, 25 patients showed cirrhosis. Using serum samples stored at -70 degrees C, liver enzymes, anti-Hbs, and IgG anti-HBc were measured via EIA and serum HBV DNA was quantified via real time PCR.RESULTS:
IgG anti-HBc seropositivity, an indicator of past infection, was higher in group II (64.7%) than in group I (43.4%; p<0.01). Eleven of 283 patients (3.2%) were seropositive for HBV DNA, indicating occult infection, but this value did not differ between groups (group I 3.5%, 7/198; group II 4.7%, 4/85; p=0.64). In group II, HBV DNA seropositivity was higher in cirrhotic patients (12%, 3/25) than in non-cirrhotic alcoholic liver disease (1.7%, 1/60; p=0.074).CONCLUSIONS:
Past HBV infection was more prevalent in alcoholics than non-alcoholics, but the prevalence of occult HBV infection did not differ between groups. However, alcoholics with cirrhosis tended to show a higher prevalence of occult HBV infection.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 -Target 3.5 Prevention and treatment of consumption of psychoactive substances
Health problem:
Target 3.5: Prevention and treatment of consumption of psychoactive substances
/
Alcohol
Database:
WPRIM (Western Pacific)
Main subject:
Fibrosis
/
DNA
/
Immunoglobulin G
/
Hepatitis B virus
/
Prevalence
/
Risk Factors
/
Alcoholism
/
Alcoholics
/
Real-Time Polymerase Chain Reaction
/
Hepatitis
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2008
Document type:
Article