Effects of Repetitive Transcranial Magnetic Stimulation on Locomotor Outcome of Spinal Cord Injured Rats / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 228-230, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-965259
Responsible library:
WPRO
ABSTRACT
@#Objective To explore the effect of repetitive transcranial magnetic stimulation(rTMS)on spinal cord injured rats.Methods Weight-drop spinal cord injury model was made at thoracic 10 segments with NYU impactor device.Stimulated group received daily superthreshold rTMS continued for 4 weeks.BBB locomotor scores were recorded weekly.Growth associated protein 43(GAP43)and 5-hydroxytryptamine(5-HT)were detected with immunofluorescence staining in the area of rostral and caudal to the lesion.Results The BBB scores in stimulation group improved compared with that in the control(P<0.01).GAP43 and 5-HT markers increased in the stimulation group(P<0.01),and they increased in the rostral than in the caudal areas(P<0.01).Conclusion rTMS can improve the locomotor function of incomplete spinal cord injury rats,which may result from the increase of expression of GAP43 and 5-HT.
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Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2008
Document type:
Article