Clinical features of 19 patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 132-136, 2023.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-969688
Responsible library:
WPRO
ABSTRACT
Objective:
To assess the clinical characteristics and prognosis of patients with SIL-TAL1-positive T-cell acute lymphoblastic leukemia (T-ALL) .Methods:
The clinical data of 19 SIL-TAL1-positive T-ALL patients admitted to the First Affiliated Hospital of Soochow University between January 2014 and February 2022 were retrospectively computed and contrasted with SIL-TAL1-negative T-ALL patients.Results:
The median age of the 19 SIL-TAL1-positive T-ALL patients was 15 (7 to 41 years) , including 16 males (84.2%) . SIL-TAL1-positive T-ALL patients had younger age, higher WBC, and hemoglobin compared with SIL-TAL1-negative T-ALL patients. There was no discrepancy in gender distribution, PLT, chromosome abnormality distribution, immunophenotyping, and complete remission (CR) rate. The 3-year overall survival (OS) was 60.9% and 74.4%, respectively (HR=2.070, P=0.071) . The 3-year relapse-free survival (RFS) was 49.2% and 70.6%, respectively (HR=2.275, P=0.040) . The 3-year RFS rate of SIL-TAL1-positive T-ALL patients was considerably lower than SIL-TAL1-negative T-ALL patients.Conclusion:
SIL-TAL1-positive T-ALL patients were connected to younger age, higher WBC, higher HGB, and poor outcome.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
T-Lymphocytes
/
Oncogene Proteins, Fusion
/
Retrospective Studies
/
Chromosome Aberrations
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
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T-Cell Acute Lymphocytic Leukemia Protein 1
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2023
Document type:
Article