Research progress of fibroblast growth factor in nervous system diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 738-749, 2023.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-971085
Responsible library:
WPRO
ABSTRACT
Fibroblast growth factors (FGF) are a group of structurally related polypeptides which constitute an elaborate signaling system with their receptors. Evidence accumulated in the years suggests that the FGF family plays a key role in the repair of central nervous system injury. The main protective mechanisms include activating the expression of PI3K-Akt, peroxisome proliferator-activated receptor (PPARγ) and other signals; inhibiting NF-κB-mediated inflammatory response, oxidative stress and apoptosis; regulating neuronal differentiation and neuronal excitability as well as participating in protection of neurovascular units and nerve function repair. This paper comprehensively summarizes the latest research progress in FGF signaling related to diseases of the central nervous system such as cerebral infarction, cerebral hemorrhage, traumatic brain injury, Alzheimer's disease, Parkinson's disease, epilepsy and depression, aiming to provide scientific basis and reference for the development of innovative FGF drugs for the prevention and treatment of neurological diseases.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Central Nervous System
/
Phosphatidylinositol 3-Kinases
/
Alzheimer Disease
/
Fibroblast Growth Factors
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2023
Document type:
Article