Advances of Immunotherapy Resistance and Coping Strategies
in Non-small Cell Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 66-77, 2023.
Article
in Zh
| WPRIM
| ID: wpr-971181
Responsible library:
WPRO
ABSTRACT
Immunotherapy has significantly improved clinical outcomes of non-small cell lung cancer (NSCLC), however, along with the popularization of immunotherapy, immune resistance has become an unavoidable problem. Immunotherapy can induce extensive cellular and molecular alterations in the tumor microenvironment. Considering the mechanisms of immune resistance are not yet fully understood and the efficacy of standard chemotherapy regimens is limited, more effective coping strategies based on resistance mechanisms are urgently needed. In this review, we intend to summarize the known mechanisms of immune resistance and feasible strategies, so as to provide a foundation for clinicians to develop more individualized and precise regimens and finally improve patients' prognosis.
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Key words
Full text:
1
Database:
WPRIM
Main subject:
Prognosis
/
Carcinoma, Non-Small-Cell Lung
/
Tumor Microenvironment
/
Immunotherapy
/
Lung Neoplasms
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Lung Cancer
Year:
2023
Document type:
Article