Anti-inflammatory sesquiterpene polyol esters from the stem and branch of Tripterygium wilfordii / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 233-240, 2023.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-971681
Responsible library:
WPRO
ABSTRACT
The stem and branch extract of Tripterygium wilfordii (Celastraceae) afforded seven new dihydroagarofuran sesquiterpene polyesters [tripterysines A-G (1-7)] and eight known ones (8-15). The chemical structures of these new compounds were established based on combinational analysis of HR-ESI-MS and NMR techniques. The absolute configurations of tripterysines A-C (1-3) and E-G (5-7) were determined by X-ray crystallographic analysis and circular dichroism spectra. All the compounds were screened for their inhibitory effect on inflammation through determining their inhibitory effect on nitric oxide production in LPS-induced RAW 264.7 cells and the secretion of inflammatory cytokines TNF-α and IL-6 in LPS-induced BV2 macrophages. Compound 9 exhibited significant inhibitory activity on NO production with an IC50 value of 8.77 μmol·L-1. Moreover, compound 7 showed the strongest inhibitory effect with the secretion of IL-6 at 27.36%.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Sesquiterpenes
/
Molecular Structure
/
Lipopolysaccharides
/
Interleukin-6
/
Plant Leaves
/
Tripterygium
/
Esters
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Anti-Inflammatory Agents
/
Nitric Oxide
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2023
Document type:
Article