Weight management intervention in overweight and obese subjects with recently diagnosed type 2 diabetes / Монголын Анагаах Ухаан

ABSTRACT

GoalAim of this study was to evaluate the effectiveness of weight loss intervention in overweight and obesepatients with newly diagnosed type 2 diabetes mellitus (T2D).Materials and Methods92 overweight and obese subjects (42 men and 50 women), aged 32-56 years, with recently diagnosedtype 2 diabetes were enrolled to the prospective cohort study. A 6-month counselingbased interventionwas conducted between December 2011 and June 2012. Participants were Mongolian and receivededucation sessions on healthy lifestyle guidelines including nutrition and physical activity in smallgroups. Before and after intervention, body weight (kg), body fat (%), waist and hip circumferences(cm), blood pressure (mm Hg), fasting blood glucose (mmol/l), HbA1C (%), total cholesterol (mmol/L)and triglyceride (mmol/L) were measured.Results80 out of 92 (86.9%) overweight and obese patients with T2D (BMI 31.57±4.2) completed weightloss intervention. Results of this study before and after the intervention showed mean body weight84.41±13.08 vs 80.11±12.42, p<0.0001; BMI 31.57±4.2 vs 29.87±3.72, p<0.0001; waist circumference104.18±10.51 vs 99.78±8.52, p<0.0001); hip circumference 107.04±8.66 vs 105.38±7.79, p<0.01;WHR 0.96±0.07 vs 0.94±0.05, p<0.0005; body fat 36.19±5.64 vs 34.26±6.57, p<0.0005; systolic bloodpressure 133.03±22.5 vs 127.54±17.5, p<0.01; diastolic blood pressure 81.18±13.14 vs 77.61±11.03,p<0.05; fasting blood glucose 11.57±4.06 vs 7.99±2.64, p<0.0001; HbA1C 8.45±2.70 vs 5.95±1.70,p<0.0001; and total cholesterol 3.87±1.05 vs 3.15±0.96, p<0.0001were improved significantly, excepttriglyceride 2.11±0.82 vs 1.73±1.8, p=0.0519. Thus results of the study showed an average weight lossof 4.3 kg and a significant decrease in BMI, percent body fat, and waist and hip circumferences, waist tohip ratio at 6 month. Significant reduction found in levels of fasting glucose, HbA1c and total cholesterolin blood after intervention, however no significant change found in blood level of triglyceride. Systolicand diastolic blood pressures were reduced significantly.ConclusionWeight reduction of 5.1% of body weight in overweight and obese subjects with type 2 diabetes bythe lifestyle intervention for 6 months resulted in significant reductions in total, abdominal and trunkadiposity and reduced blood pressure and improved glycemic control and dislipidemia.