Research progress of flavivirus vaccines based on adenovirus vector / 预防医学
Journal of Preventive Medicine
; (12): 677-681, 2023.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-980300
Responsible library:
WPRO
ABSTRACT
@#There are more than 70 species of flaviviruses, including Zika virus, Dengue virus and Japanese encephalitis virus, and more than 33 species are known to be capable of infecting humans. Only three flavivirus vaccines have been approved, and there is a lack of safe and effective vaccines for most flaviviruses. Adenovirus-vectored vaccines have high safety, low cost, and convenience to store and transport. Currently, two adenovirus-vectored Zika vaccines are under early clinical trials, and adenovirus-vectored vaccines for Dengue virus, Japanese encephalitis virus, West Nile virus and yellow fever virus are still in the phase of animal experiment. In the development of adenovirus-vectored flavivirus vaccines, there are still problems of pre-existing immunity to adenovirus, the insufficient immunogenicity of adenovirus vectors and the antibody-dependent enhancement effects among flavivirus. Based on relevant publications from January 2006 to June 2023, this article reviews the current status, challenges and solutions of the research into adenovirus-vectored flavivirus vaccines, so as to provide the reference for the development of relevant vaccines.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Dengue
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Preventive Medicine
Year:
2023
Document type:
Article