Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 501-509, 2023.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-981080
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline (BR) and the conventional treatment regimen (CR, not containing Bedaquiline) for the treatment of adults with multidrug-resistant tuberculosis (MDR-TB) in China.@*METHODS@#A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years. The model parameter data were synthesized from the literature, the national TB surveillance information system, and consultation with experts. The incremental cost-effectiveness ratio (ICER) of BR vs. CR was determined.@*RESULTS@#BR ( vs. CR) had a higher sputum culture conversion rate and cure rate and prevented many premature deaths (decreased by 12.8%), thereby obtaining more quality-adjusted life years (QALYs) (increased by 2.31 years). The per capita cost in BR was as high as 138,000 yuan, roughly double that of CR. The ICER for BR was 33,700 yuan/QALY, which was lower than China's 1× per capita Gross Domestic Product (GDP) in 2020 (72,400 yuan).@*CONCLUSION@#BR is shown to be cost effective. When the unit price of Bedaquiline reaches or falls below 57.21 yuan per unit, BR is expected to be the dominant strategy in China over CR.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
Neglected Diseases
Health problem:
Goal 4: Health financing
/
Neglected Diseases
/
Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
China
/
Cost-Benefit Analysis
/
Tuberculosis, Multidrug-Resistant
/
Cost-Effectiveness Analysis
/
Antitubercular Agents
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2023
Document type:
Article