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Prenatal diagnosis and genetic analysis of a fetus with partial deletion of Yq and mosaicism of 45,X / 中华医学遗传学杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-981819
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To carry out prenatal diagnosis and genetic analysis for a fetus with disorders of sex development (DSDs).@*METHODS@#A fetus with DSDs who was identified at the Shenzhen People's Hospital in September 2021 was selected as the study subject. Combined molecular genetic techniques including quantitative fluorescence PCR (QF-PCR), multiplex ligation-dependent probe amplification (MLPA), chromosomal microarray analysis (CMA), quantitative real-time PCR (qPCR), as well as cytogenetic techniques such as karyotyping analysis and fluorescence in situ hybridization (FISH) were applied. Ultrasonography was used to observe the phenotype of sex development.@*RESULTS@#Molecular genetic testing suggested that the fetus had mosaicism of Yq11.222qter deletion and X monosomy. Combined with the result of cytogenetic testing, its karyotype was determined as mos 45,X[34]/46,X,del(Y)(q11.222)[61]/47,X,del(Y)(q11.222),del(Y)(q11.222)[5]. Ultrasound examination suggested hypospadia, which was confirmed after elective abortion. Combined the results of genetic testing and phenotypic analysis, the fetus was ultimately diagnosed with DSDs.@*CONCLUSION@#This study has applied a variety of genetic techniques and ultrasonography to diagnose a fetus with DSDs with a complex karyotype.
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Prenatal Diagnosis / Chromosomes, Human, X / Chromosomes, Human, Y / Mosaicism Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2023 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Prenatal Diagnosis / Chromosomes, Human, X / Chromosomes, Human, Y / Mosaicism Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2023 Document type: Article
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