Your browser doesn't support javascript.
loading
Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Article in English | WPRIM (Western Pacific) | ID: wpr-982368
Responsible library: WPRO
ABSTRACT
Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and "pre-necrotic" biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: RNA / Biomarkers / Computational Biology / RNA, Untranslated / MicroRNAs / Myocardial Infarction Limits: Humans Language: English Journal: Journal of Zhejiang University. Science. B Year: 2023 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: RNA / Biomarkers / Computational Biology / RNA, Untranslated / MicroRNAs / Myocardial Infarction Limits: Humans Language: English Journal: Journal of Zhejiang University. Science. B Year: 2023 Document type: Article
...