Lethal anaphylactic shock model induced by human mixed serum in guinea pigs / 法医学杂志
Journal of Forensic Medicine
; (6): 169-170, 2005.
Article
in Zh
| WPRIM
| ID: wpr-983099
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To establish an anaphylactic shock model induced by human mixed serum in guinea pigs.@*METHODS@#Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.@*RESULTS@#Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.@*CONCLUSIONS@#An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.
Full text:
1
Database:
WPRIM
Main subject:
Immunoglobulin G
/
Radioimmunoassay
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Allergens
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Random Allocation
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Death, Sudden
/
Serum
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Disease Models, Animal
/
Forensic Medicine
/
Guinea Pigs
/
Anaphylaxis
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2005
Document type:
Article