Experimental pathological study of acute intoxication by Chloranthus serratus Roem. Et Schalt / 法医学杂志
Journal of Forensic Medicine
; (6): 15-17, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-983119
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To find out the pathological change and the toxic mechanism of Chloranthus serratus Roem. et Schalt in mice.@*METHODS@#Mice were intoxicated by oral administration with extracts of Chloranthus serratus Roem. et Schalt followed by pathological, serum biochemical, and coagulation mechanism examination.@*RESULTS@#The LD50 in mice was 41.12 g/kg; All poisoned mice serum BUN and ALT increased markedly; Thrombocyte decreased and coagulation time increased; The organ index of liver, spleen and kidneys increased significantly; The cells of liver, kidney and heart were degeneration and necrosis, There were extensive hyperemia and hemorrhage in many organs.@*CONCLUSION@#The experiment suggests that the target organs were liver, kidney, heart and blood vessels; The toxic mechanism was the damage on the mitochondrional, endoplasmic reticulum and coagulation system.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Mitochondria, Liver
/
Plant Extracts
/
Biomarkers
/
Random Allocation
/
Magnoliopsida
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Forensic Pathology
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Dose-Response Relationship, Drug
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Endoplasmic Reticulum
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Kidney
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Lethal Dose 50
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2006
Document type:
Article