Screening and confirmation of psychotropic drugs in blood and urine by HPLC-LTQ Orbitrap MS / 法医学杂志
Journal of Forensic Medicine
; (6): 44-48, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-983712
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To establish a screening and confirmation method for psychotropic drugs and their metabolites in human blood and urine by HPLC-LTQ Orbitrap MS.@*METHODS@#The samples were pretreated with Sirocco protein precipitation plate, and then analyzed by HPLC-LTQ Orbitrap MS. The method was validated in terms of the limit of detection (LOD). An accurate mass database was created for psychotropic drugs screening.@*RESULTS@#The LOD for most of 56 determined compounds was < or = 0.1 ng/mL. The accurate mass database included the accurate mass information of 61 psychotropic drugs.@*CONCLUSION@#The method is accurate, rapid, sensitive and the database is suitable for psychotropic drugs screening and confirmation.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Psychotropic Drugs
/
Mass Spectrometry
/
Molecular Structure
/
Substance Abuse Detection
/
Reproducibility of Results
/
Chromatography, High Pressure Liquid
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Sensitivity and Specificity
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Forensic Toxicology
/
Molecular Weight
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2012
Document type:
Article