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Screening and confirmation of psychotropic drugs in blood and urine by HPLC-LTQ Orbitrap MS / 法医学杂志
Journal of Forensic Medicine ; (6): 44-48, 2012.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-983712
Responsible library: WPRO
ABSTRACT
OBJECTIVE@#To establish a screening and confirmation method for psychotropic drugs and their metabolites in human blood and urine by HPLC-LTQ Orbitrap MS.@*METHODS@#The samples were pretreated with Sirocco protein precipitation plate, and then analyzed by HPLC-LTQ Orbitrap MS. The method was validated in terms of the limit of detection (LOD). An accurate mass database was created for psychotropic drugs screening.@*RESULTS@#The LOD for most of 56 determined compounds was < or = 0.1 ng/mL. The accurate mass database included the accurate mass information of 61 psychotropic drugs.@*CONCLUSION@#The method is accurate, rapid, sensitive and the database is suitable for psychotropic drugs screening and confirmation.
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Psychotropic Drugs / Mass Spectrometry / Molecular Structure / Substance Abuse Detection / Reproducibility of Results / Chromatography, High Pressure Liquid / Sensitivity and Specificity / Forensic Toxicology / Molecular Weight Limits: Humans Language: Chinese Journal: Journal of Forensic Medicine Year: 2012 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Psychotropic Drugs / Mass Spectrometry / Molecular Structure / Substance Abuse Detection / Reproducibility of Results / Chromatography, High Pressure Liquid / Sensitivity and Specificity / Forensic Toxicology / Molecular Weight Limits: Humans Language: Chinese Journal: Journal of Forensic Medicine Year: 2012 Document type: Article
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