Magnetic resonance diffusion tensor imaging for diagnosis of pyramidal tract damage in rats / 法医学杂志
Journal of Forensic Medicine
; (6): 256-268, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-983744
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore the applicability of magnetic resonance diffusion tensor imaging (DTI) for diagnosis of pyramidal tract damage in rats.@*METHODS@#Marmarou's model was set up, followed by DTI scanning at 3, 12, 24 and 72 h post trauma to acquire the dispersion parameter of bilateral pyramidal tracts. Moreover, axonal varicosities per square millimeter and the percentage of positive area of axons demonstrated by beta-amyloid precursor protein (beta-APP) immunostaining were obtained, as well as the mean density and sum density of neurofilament (NF) 68 immunostaining.@*RESULTS@#Axial diffusivity (AD), fraction anisotropy (FA) and relative anisotropy (RA) in the pyramidal tract were significantly and continuously reduced and reached to the bottom at 72h post trauma (P < 0.05) in accord with the gradient of axonal damage verified by beta-APP and NF68 immunostaining. Furthermore, the changes of AD, FA and RA showed a significant negative correlation with the beta-APP immunohistochemical results.@*CONCLUSION@#DTI has important value for early diagnosis in pyramidal tract damage.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pyramidal Tracts
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Axons
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Time Factors
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Severity of Illness Index
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Image Processing, Computer-Assisted
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Brain
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Brain Injuries
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Neurofilament Proteins
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Anisotropy
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Amyloid beta-Protein Precursor
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2012
Document type:
Article