Research Progress on the Detection Method of DNA Methylation and Its Application in Forensic Science / 法医学杂志
Journal of Forensic Medicine
; (6): 293-300, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-984896
Responsible library:
WPRO
ABSTRACT
As an important part of epigenetic marker, DNA methylation involves in the gene regulation and attracts a wide spread attention in biological auxology, geratology and oncology fields. In forensic science, because of the relative stable, heritable, abundant, and age-related characteristics, DNA methylation is considered to be a useful complement to the classic genetic markers for age-prediction, tissue-identification, and monozygotic twins' discrimination. Various methods for DNA methylation detection have been validated based on methylation sensitive restriction endonuclease, bisulfite modification and methylation-CpG binding protein. In recent years, it is reported that the third generation sequencing method can be used to detect DNA methylation. This paper aims to make a review on the detection method of DNA methylation and its applications in forensic science.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Sulfites
/
Twins, Monozygotic
/
Genetic Markers
/
CpG Islands
/
DNA Methylation
/
Epigenesis, Genetic
/
Forensic Genetics
/
Epigenomics
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2017
Document type:
Article