Progress of unfolded protein response in acute respiratory distress syndrome / 国际儿科学杂志
International Journal of Pediatrics
; (6): 393-396, 2023.
Article
in Zh
| WPRIM
| ID: wpr-989102
Responsible library:
WPRO
ABSTRACT
Acute respiratory distress syndrome(ARDS)is a severe respiratory disease in children and the pathogenesis is not fully defined.It is mainly related to various mechanisms of lung injury such as inflammation and autophagy.In recent years, studies have found that, endoplasmic reticulum stress(ERS)can aggravate lung injury in ARDS, in which protein homeostasis imbalance can induce activation of the unfolded protein response(UPR).The UPR reconstructs homeostasis by mediating transmembrane protein-related signaling pathways, while continuous excessive ERS will promote apoptosis and autophagy.This review summarizes the progress of the signaling pathway of UPR related to lung injury and its inflammatory effect in ARDS.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
International Journal of Pediatrics
Year:
2023
Document type:
Article