Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
Genomics & Informatics
; : 59-63, 2011.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-98932
Responsible library:
WPRO
ABSTRACT
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Cardiovascular Diseases
/
Body Mass Index
/
Cohort Studies
/
Receptor, Melanocortin, Type 4
/
Asian People
/
Genome-Wide Association Study
/
Genetic Loci
/
Obesity
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Genomics & Informatics
Year:
2011
Document type:
Article