Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model / 한국실험동물학회지
Laboratory Animal Research
; : 137-140, 2012.
Article
in En
| WPRIM
| ID: wpr-98976
Responsible library:
WPRO
ABSTRACT
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase-2-PGE2 pathways.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Dexamethasone
/
Dinoprostone
/
Carrageenan
/
Cell Count
/
Indomethacin
/
Administration, Oral
/
Tumor Necrosis Factor-alpha
/
Houttuynia
/
Exudates and Transudates
/
Inflammation
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Laboratory Animal Research
Year:
2012
Document type:
Article