Gut microbiota and the coronavirus disease 2019 / 中国小儿急救医学

ABSTRACT

Gut microbiota regulates the immune response of distal organs through microbiota-metabolites, microbiota related molecular patterns and interactions between microorganisms and immune cells.The gut microbiota can be affected by direct infection of intestine or indirect immunity in coronavirus disease 2019 (COVID-19) epidemic caused by SARS-CoV-2.The gut microbiota can also affect the virus through the diversity of microbiota and the interaction of specific microorganisms and viruses or their metabolites.Beneficial bacteria such as Bifidobacterium adolescentis in the gut microbiota can promote the production of antibodies against COVID-19 vaccine, including inactivated vaccine and RNA vaccine.Microbiota disorder has a long-term impacts on some COVID-19 patients, and interventions of gut microbiota, such as fecal microbiota transplantation, having a certain effect on the treatment of COVID-19.