Epidemiological characteristics and risk factors of myocardial injury in patients with diabetes mellitus complicated with coronary heart disease in Qingdao area / 公共卫生与预防医学

ABSTRACT

Objective To analyze the epidemiological characteristics and risk factors of myocardial injury in diabetes patients with coronary heart disease in Qingdao, and to provide a theoretical basis for the prevention of myocardial injury in diabetes patients with coronary heart disease. Methods A total of 196 diabetes patients with coronary heart disease admitted to the Affiliated Hospital of Qingdao University from June 2019 to June 2020 were selected. The patients were divided into myocardial injury group (n=39) and non-myocardial injury group (n=157) according to whether myocardial injury occurred during hospitalization. Four ml of fasting elbow venous blood was collected from all subjects. The serum cTnT, BNP and CK-MB levels of the two groups were compared. The clinical data of the patients were collected from the medical record system, including gender, age, history of taking lipid-lowering drugs, BMI, diabetes mellitus, course of coronary heart disease and serum TG, FPG, PBG, HbAlc, HDL-C, LDL-C levels, etc. Univariate analysis and logistic regression analysis were used to analyze the influencing factors of myocardial injury in patients with diabetes mellitus complicated with coronary heart disease. Results Among of 196 diabetic patients with coronary heart disease, 39 cases (19.90%) had myocardial injury, including 21 males and 18 females. There was no difference in gender between the two groups (χ2=0.105, P>0.05). The age of patients in the myocardial injury group (64.78±5.67) was significantly higher than that in the control group (59.72±5.12) (t =5.016, P<0.05). The serum levels of cTnT, BNP and CK-MB in the myocardial injury group were significantly higher than those in the control group (P<0.05). There were significant differences in the course of coronary heart disease, serum Hcy, TG, FPG, PBG, HbAlc, TG and LDL-C between the two groups (P<0.05). Increased Hcy (OR=2.673), increased FBG (OR=3.681) and increased LDL-C (OR=2.912) were risk factors for myocardial injury in patients with diabetes mellitus complicated with coronary heart disease (P<0.05). Conclusion The risk of myocardial injury in patients with diabetes combined with coronary heart disease in Qingdao area is high, which is closely related to the increase of postprandial LDL-C, FBG and Hcy in patients. Active intervention should be given to reduce the risk of myocardial injury.