Preclinical Voxel-Based Dosimetry in Theranostics: a Review / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
; : 86-97, 2020.
Article
in En
| WPRIM
| ID: wpr-997473
Responsible library:
WPRO
ABSTRACT
Due to the increasing use of preclinical targeted radionuclide therapy (TRT) studies for the development of novel theranosticagents, several studies have been performed to accurately estimate absorbed doses to mice at the voxel level using referencemouse phantoms and Monte Carlo (MC) simulations. Accurate dosimetry is important in preclinical theranostics to interpretradiobiological dose-response relationships and to translate results for clinical use. Direct MC (DMC) simulation is believed toproduce more realistic voxel-level dose distribution with high precision because tissue heterogeneities and nonuniform sourcedistributions in patients or animals are considered. Although MC simulation is considered to be an accurate method for voxelbasedabsorbed dose calculations, it is time-consuming, computationally demanding, and often impractical in daily practice. Inthis review, we focus on the current status of voxel-based dosimetry methods applied in preclinical theranostics and discuss theneed for accurate and fast voxel-based dosimetry methods for pretherapy absorbed dose calculations to optimize the dosecomputation time in preclinical TRT.
Full text:
1
Database:
WPRIM
Language:
En
Journal:
Korean Journal of Nuclear Medicine
Year:
2020
Document type:
Article