Metallic limus-eluting stents abluminally coated with biodegradable polymers: angiographic and clinical comparison of a novel ultra-Thin sirolimus stent versus biolimus stent in the DESTINY Randomised Trial
Cardiovasc Ther
; 33(6): 367-371, 2015.
Artículo
en Inglés
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1061818
Biblioteca responsable:
BR79.1
Ubicación: BR79.1
ABSTRACT
AIMS:
To evaluate the outcomes of patients treated with a new drug-eluting stent formulation with low doses of sirolimus, built in an ultra-thin-strut platform coated with biodegradable abluminal coating.METHODS:
This study is a randomized trial that tested the main hypothesis that the angiographic late lumen loss of the novel sirolimus-eluting stent is noninferior compared with commercially available biolimus-eluting stent. A final study population comprising 170 patients with one or two de novo lesions was randomized in the ratio 21 for sirolimus-eluting stent or biolimus-eluting stent, respectively. The primary endpoint was 9-month angiographic in-stent late lumen loss. Adverse clinical events were prospectively collected for 1 year.RESULTS:
After 9 months, the novel sirolimus-eluting stent was shown noninferior compared with the biolimus stent for the primary endpoint (angiographic in-stent late lumen loss 0.20 ± 0.29 mm vs. 0.15 ± 0.20 mm, respectively; P value for noninferiority <0.001). The 1-year incidence of death, myocardial infarction, repeat revascularization, and stent thrombosis remained low and not significantly different between the groups.CONCLUSIONS:
The present randomized trial demonstrates that the tested novel sirolimus-eluting stent was angiographically noninferior in comparison with a last-generation biolimus-eluting stent.
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Colección:
Bases de datos nacionales
/
Brasil
Base de datos:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Stents
/
Aterosclerosis
Tipo de estudio:
Ensayo clínico controlado
Idioma:
Inglés
Revista:
Cardiovasc Ther
Año:
2015
Tipo del documento:
Artículo
Institución/País de afiliación:
Faculdade de Ciências Médicas da Santa Casa de São Paulo/BR
/
Heart Institute (InCor), University of São Paulo Medical School/BR
/
Hospital Bandeirantes/BR
/
Hospital Cardiológico Costantini/BR
/
Hospital Encore/BR
/
Hospital Santa Izabel/BR
/
Hospital Santa Marcelina/BR
/
Hospital do Servidor Público Estadual - IAMSPE/BR
/
Fundação Universitária de Cardiologia de Porto Alegre+BR
/
Instituto Dante Pazzanese de Cardiologia/BR