Plasmodium falciparum: Restricted Polymorphism of T Cell Epitopes of the Circumsporozoite Protein in Brazil
Exp.Parasitology
; 71: 386-392, apr.-1990. map, tab
Article
en En
| SES-SP, SESSP-SUCENPROD, SES-SP
| ID: biblio-1062774
Biblioteca responsable:
BR93.2
Ubicación: BR93.2
ABSTRACT
We examined the extent of variation of the 3 region of the circumsporozoite gene among Plasmodium falaciparum isolates through amplification of a selected DNA fragment followed by DNA sequencing. A total of 32 isolates were analyzed, of which 24 were from Amazon endemic areas in Brazil and 8 from widely separated geographical regions in the world. Among Brazilian isolates only 2 variants were detected 19 displayed the same sequence of strain 7G8 whereas the 4 remaining isolates differed from the 7G8 strain at five nucleotide positions which also led to amino acid changes. Variation was restricted to one of the T-helper epitopes while the sequence identified as a cytotoxic T cell epitope was conserved in all Brazilian isolates. P. falciparum samples from other geographical regions in the world showed sequences distinct from those of Brazilian isolates. However, some constancy could be observed within that variation. For instance, the most frequent nucleotide substitutions, from A to C at nucleotide positions 1015 and 1024m were same in all isolates.
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Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-SUCENPROD
Asunto principal:
Plasmodium falciparum
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Exp.Parasitology
Año:
1990
Tipo del documento:
Article