Neonatal immunization with a single dose of recombinant BCG expressing subunit S1 from pertussis toxin induces complete protection against Bordetella pertussis intracerebral challenge
Microbes and Infection
; 10(2): 198-202, 2008.
Article
en En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1064737
Biblioteca responsable:
BR78.1
Ubicación: BR78.1
ABSTRACT
The currently used pertussis vaccines are highly efficacious; however, neonates are susceptible to whooping cough up to the sixth month. In agreement, DTP-immunized neonate mice were not protected against intracerebral challenge with Bordetella pertussis. Neonate mice immunized with either DTP or a recombinant-BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin do not show a humoral immune response against PT. On the other hand, rBCG-Pertussis induces higher PT-specific IFN-ã production and an increase in both IFN-ã+ and TNF-á+-CD4+-T cells than the whole cell pertussis vaccine and confers protection against a lethal intracerebral challenge with B. pertussis
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Colección:
06-national
/
BR
Base de datos:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Asunto principal:
Bordetella pertussis
/
Vacuna BCG
/
Vacuna contra la Tos Ferina
/
Vacuna contra Difteria, Tétanos y Tos Ferina
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Microbes and Infection
Año:
2008
Tipo del documento:
Article