Randomized trial of benznidazole for chronic Chagas' cardiomyopathy
N Engl J Med
; 373(14): 1295-1306, 2015. tab
Artículo
en Inglés
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1064855
Biblioteca responsable:
BR79.1
Ubicación: BR79.1
ABSTRACT
BACKGROUND:
The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven.METHODS:
We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed for a mean of 5.4 years. The primary outcome in the time-to-event analysis was the first event of any of the components of the composite outcome of death, resuscitated cardiac arrest, sustained ventricular tachycardia, insertion of a pacemaker or implantable cardioverter-defibrillator, cardiac transplantation, new heart failure, stroke, or other thromboembolic event.RESULTS:
The primary outcome occurred in 394 patients (27.5%) in the benznidazole group and in 414 (29.1%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.81 to 1.07; P=0.31). At baseline, a polymerase-chain-reaction (PCR) assay was performed on blood samples obtained from 1896 patients; 60.5% had positive results for Trypanosoma cruzi on PCR. The rates of conversion to negative PCR results (PCR conversion) were 66.2% in the benznidazole group and 33.5% in the placebo group at the end of treatment, 55.4% and 35.3%, respectively, at 2 years, and 46.7% and 33.1%, respectively, at 5 years or more (P<0.001 for all comparisons)...
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
Brasil
Contexto en salud:
ODS3 - Salud y Bienestar
/
Enfermedades Desatendidas
/
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
/
Enfermedad de Chagas
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Enfermedades Desatendidas
/
Enfermedad Cardiovascular
/
Otras Enfermedades Circulatorias
Base de datos:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Asunto principal:
Cardiomiopatía Chagásica
/
Enfermedad de Chagas
Tipo de estudio:
Ensayo clínico controlado
Idioma:
Inglés
Revista:
N Engl J Med
Año:
2015
Tipo del documento:
Artículo
Institución/País de afiliación:
CIMPATFacultad de Ciencias, Universidad de los Andes/CO
/
Cardiology Division, Internal Medicine Department, MedicalSchool of Riberao Preto/BR
/
Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas/BR
/
Fundación Cardiovascular de Colombia/CO
/
Fundación Clínica Abood Shaio/CO
/
Hospital Nacional Rosales/SV
/
Hospital do Coração Anis Rassi/BR
/
HospitalEduardo Eguia, Programa Chagas/BO
/
IndependentAdvisor, Neglected Tropical Diseases/CH
/
Instituto Dante Pazzanese de Cardiologia/BR