The effects of valproic acid on skin healing: experimental study in rats
Acta cir. bras
; 37(4): e370403, 2022. tab
Article
en En
| VETINDEX
| ID: biblio-1383304
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
ABSTRACT
Purpose:
To recognize the effects of valproic acid (VPA), an epigenetic drug, on the skin healing process.Methods:
Sixty male Wistar rats were divided into two groups the experiment treated with VPA (100 mg/kg/day); and the control, with 0.9% sodium chloride by gavage. Skin healing was studied in three moments (the third, the seventh, and the 14th day), evaluating the parameters inflammatory reaction and its intensity (anti-LCA), angiogenesis (anti-CD34), collagen I and III (anti-collagen I, anti-collagen III and Picrosirius-red F3BA) and myofibroblasts (anti-alpha-AMS).Results:
The inflammatory reaction was acute or sub-acute in both groups on the third day. On the seventh and the 14th day, chronic predominated in the control (p=0.006), and sub-acute in the experiment (p=0.020). There was a greater number of leukocytes in the group treated only on the third day (p=0.036). The number of vessels was lower in the treated group at the three times (p3=0.002, p7<0.001, and p14=0.027). Myofibroblasts were rare in the third day and moderate quantity in the remaining periods. Collagen I density was higher in the control at the three times (p<0.001) and collagen III in the treated group (p<0.001).Conclusions:
VPA led to a more intense inflammatory reaction, decreased angiogenesis and collagen deposition, especially type I collagen.Palabras clave
Texto completo:
1
Base de datos:
VETINDEX
Asunto principal:
Cicatrización de Heridas
/
Ácido Valproico
/
Ratas Wistar
/
Colágeno Tipo I
/
Epigénesis Genética
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Año:
2022
Tipo del documento:
Article