Identification Des Nouveaux Progrès Sur Les Molécules Dérivées Du Pyrazole Comme AgentsAntimicrobiens Et Antifongiques
West Afr. j. med
; 39(11): 1217-1244, 2022. tales, figures
Article
en En
| AIM
| ID: biblio-1411031
Biblioteca responsable:
CG1.1
ABSTRACT
Microbial infections remain a worldwide leading cause of death,despite the evolution of a large number of new antibiotics everyyear. Currently, several bacteria have developed resistanceagainst antibiotics drugs which remain a major issue inantibiotics drug discovery. This review provides detailedinformation about antimicrobial and antifungal agent synthesisbelonging to the pyrazoles scaffold. We reassemble the resultsobtained from several studies to characterize the importance ofheteroatom nuclei in many synthetic products. Additionally,several compounds based on pyrazole derivatives such asbenzimidazole, benzothiazole, indole, acridine, oxadiazole,imidazole, isoxazole, pyrazole, triazole, quinoline and quinazolineincluding other pyrazole containing drugs such as pyridazine,pyridine and pyrimidine are highlighted. Furthermore, you willfind in this review 134 best promise structures collected fromrecent studies, relating the pyrazoles structures to the relevantbiological activities, in particular, antimicrobial and antifungalone.
Palabras clave
Texto completo:
1
Base de datos:
AIM
Asunto principal:
Farmacorresistencia Microbiana
/
Nitrógeno
Límite:
Humans
Idioma:
En
Revista:
West Afr. j. med
Año:
2022
Tipo del documento:
Article