Annexin A1 peptide Ac2-26 mitigates ventilator-induced lung injury in acute respiratory distress syndrome rats and partly depended on the endothelial nitric oxide synthase pathway
Acta cir. bras
; 37(12): e371203, 2022. graf, ilus
Article
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| ID: biblio-1415495
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
ABSTRACT
Purpose:
Although mechanical ventilation is an essential support for acute respiratory distress syndrome (ARDS), ventilation also leads to ventilator-induced lung injury (VILI). This study aimed to estimate the effect and mechanism of Annexin A1 peptide (Ac2-26) on VILI in ARDS rats.Methods:
Thirty-two rats were randomized into the sham (S), mechanical ventilation (V), mechanical ventilation/Ac2-26 (VA), and mechanical ventilation/Ac2-26/L-NIO (VAL) groups. The S group only received anesthesia, and the other three groups received endotoxin and then ventilation for 4 h. Rats in the V, VA and VAL groups received saline, Ac2-26, and A c2-26/N5-(1-iminoethyl)-l-ornithine (L-NIO), respectively.Results:
All indexes deteriorated in the V, VA and VAL groups compared with the S group. Compared with V group, the PaO2/FiO2 ratio was increased, but the wet-to-dry weight ratio and protein levels in bronchoalveolar lavage fluid were decreased in the VA group. The inflammatory cells and proinflammatory factors were reduced by Ac2-26. The oxidative stress response, lung injury and apoptosis were also decreased by Ac2-26 compared to V group. All improvements of Ac2-26 were partly reversed by L-NIO.Conclusions:
Ac2-26 mitigates VILI in ARDS rats and partly depended on the endothelial nitric oxide synthase pathway.Palabras clave
Texto completo:
1
Base de datos:
VETINDEX
Asunto principal:
Péptidos
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Síndrome de Dificultad Respiratoria del Recién Nacido
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Anexina A1
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Lesión Pulmonar Inducida por Ventilación Mecánica
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Animales de Laboratorio
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Óxido Nítrico
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Año:
2022
Tipo del documento:
Article