Five-year performance analysis of a cystic fibrosis newborn screening program in northeastern Brazil
J. pediatr. (Rio J.)
; 99(1): 23-30, Jan.-Feb. 2023. tab, graf
Article
en En
|
LILACS-Express
| LILACS
| ID: biblio-1422019
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract Objective:
To analyze the performance of the cystic fibrosis (CF) newborn screening (NBS) program over its first five years in a Brazilian northeastern state.Methods:
A population-based study using a screening algorithm based on immunoreactive trypsinogen (IRT)/IRT. Data were retrieved from the state referral screening center registry. The program performance was evaluated using descriptive indicators such as the results of an active search, coverage, newborn's age at the time of blood sampling, the time between sample collection and its arrival at the laboratory, and the child's age at diagnosis of disease.Results:
The public CF screening program covered 82.6% of the 1,017,576 births that occurred, with an accumulated five-year incidence of 120,767 live births. The median (25th-75th) age at diagnosis was 3.5 (2.3-7.3) months. The sampling before 7 days of life for the first IRT (IRT1) increased between 2013 and 2017 from 42.2 to 48.3%. Around 5% of IRT1 samples and 30% of the second samples were collected after 30 days of life. In the first and second stages of screening, 23.6% and 19.9% of the infants, respectively, were lost to follow-up. In both stages of screening, the samples were retained at the health units for a median (25th-75th) of 9.0 (7.0-13.0) days.Conclusions:
The coverage by the CF-NBS program was satisfactory as compared to other Brazilian state rates and the percentage of IRT1 samples collected within the first week of life increased progressively. However, time of samples retention at the health units, inappropriate sampling, inherent methodological problems, and loss of follow-up need to improve.
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J. pediatr. (Rio J.)
Asunto de la revista:
PEDIATRIA
Año:
2023
Tipo del documento:
Article
/
Project document
País de afiliación:
Brasil
Pais de publicación:
Brasil