Four year immunogenicity of the RTS, S/AS02 (A) malaria vaccine in Mozambican children during a phase IIb trial
Vaccine
; 29(35): [6059-6067], ago 11, 2011.
Artículo
en Inglés
| RSDM
| ID: biblio-1527242
Biblioteca responsable:
MZ1.1
ABSTRACT
Previous studies with the malaria vaccine RTS,S/AS02A in young children in a malaria endemic area of Mozambique have shown it to have a promising safety profile and to reduce the risk of Plasmodium falciparum infection and disease. In this study, we assessed the antibody responses to the P. falciparum and hepatitis B components of the RTS,S/AS02A vaccine over a 45 months surveillance period in a large phase IIb trial which included 2022 children aged 14 years at recruitment. The RTS,S/AS02A vaccine induced high anti-circumsporozoite antibody levels with at least 96% of hildren remaining seropositive during the entire follow-up period. IgG titers decayed over the first 6 months of follow-up to about 25% of the initial level, but still remained 30-fold higher until month 45 compared to controls. Children with higher levels of naturally acquired immunity at baseline, assessed by blood stage indirect fluorescent antibody test, had slightly higher anti-circumsporozoite levels, after adjusting for the effect of age. The TS,S/AS02A vaccine also induced high levels of anti-hepatitis B surface antigen antibodies (seroprotection >97%). RTS,S/AS02A vaccine is immunogenic and induces long-lasting anti-circumsporozoite antibodies, persisting at least 42 months after immunization. These antibodies may play a role in protection against malaria.
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
MZ
Base de datos:
RSDM
Asunto principal:
Niño
/
Infecciones por Enterovirus
/
Gastroenteritis
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Mozambique
Límite:
Humanos
/
Lactante
/
Recién nacido
País/Región como asunto:
Africa
Idioma:
Inglés
Revista:
Vaccine
Año:
2011
Tipo del documento:
Artículo
Institución/País de afiliación:
Hospital Clinic
/
Centro de Investigação em Saúde de Manhiça (CISM)/MZ
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Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique/MZ
/
GlaxoSmithKline Biologicals/BE
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GlaxoSmithKline, Tres Cantos/ES
/
PATH Malaria Vaccine Initiative/US