E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion
Acta cir. bras
; Acta cir. bras;39: e391724, 2024. tab, ilus
Article
en En
| LILACS, VETINDEX
| ID: biblio-1556672
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
ABSTRACT
Purpose:
To investigate inflammation and cell adhesion molecules in the vagina after ovarian ischemia-reperfusion (IR) injury.Methods:
20 Wistar albino female rats were divided into two groups control, and IR groups. In IR group, blood flow was restricted for 2 hours for ovarian ischemia. Then, tissues were re-blood 2 hours for reperfusion. Vagina tissues were excised and processed for histopathological analysis. Histopathological and biochemical follow-ups were performed.Results:
Both malondialdehyde and myeloperoxidase values were increased in IR group compared to control group. Glutathione content was decreased in IR group compared to control group. Epithelial degeneration, inflammation, dilatation, and nuclear factor-κB (NF-κB) expression were increased in IR group compared to control group. E-cadherin expression was significantly decreased in IR group. In the IR group, E-cadherin showed a positive reaction in adenomas, gland-like cryptic structures, cellular junctions with clustered inflammatory cells. In the IR group, NF-κB expression was increased in basement membrane, inflammatory cells, in blood vessels.Conclusions:
Ovarian ischemia caused degeneration of epithelial cells in the vaginal region and disruptions in the cell junction complex, which leads to activation of E-cadherin and NF-κB signaling pathway and alterations in reproductive and embryonal development in the vaginal region.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
/
VETINDEX
Asunto principal:
Ovario
/
Reperfusión
/
Cadherinas
/
FN-kappa B
/
Ratas Wistar
/
Isquemia
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2024
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Brasil