Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
An. acad. bras. ciênc
; 89(3): 1369-1379, July-Sept. 2017. tab, graf
Article
en En
| LILACS
| ID: biblio-886755
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Triterpenos
/
Lamiaceae
/
Triterpenos Pentacíclicos
/
Fabaceae
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
An. acad. bras. ciênc
Asunto de la revista:
CIENCIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil