Increased levels of cyclin D1 negatively impacts on acute lymphoblastic leukemia overall survival
Appl. cancer res
; 38: 1-4, jan. 30, 2018. tab, ilus
Article
en En
| LILACS, Inca
| ID: biblio-910442
Biblioteca responsable:
BR30.1
Ubicación: BR30.1
ABSTRACT
Background:
Cyclin D1 is a protein essential for transition from G1 to S phase during cell cycle progression, which has an oncogenic potential and is highly expressed in several human malignancies. However, in view of the heterogeneity of the findings in the literature, the prognostic value of cyclin D1 expression still needs to be validated in different cohorts of adult acute lymphoblastic leukemia (ALL) patients.Methods:
Bone marrow samples from 13 healthy donors and 45 adult patients with acute lymphoblastic leukemia were included. Cyclin D1 gene expression was evaluated by quantitative PCR. For statistical analysis, MannWhitney test, Fisher's exact test, Chi-squared test and Cox regression were used, as appropriate. All p values were two-sided with a significance level of 5%.Results:
Cyclin D1 mRNA levels were similar between primary cells from ALL patients and healthy donors. In ALL patients, high cyclin D1 expression was associated with older age at the diagnosis, presence of BCR-ABL1, and lower white blood cell counts. Importantly, increased cyclin D1 expression was an independent factor that predicted worse overall survival in our adult ALL cohort.Conclusion:
Increased levels of cyclin D1 negatively impacted on ALL survival outcome, suggesting that this gene is involved in the malignant phenotype of ALL.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
/
Inca
Asunto principal:
Pronóstico
/
Sobrevida
/
Ciclina D1
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Appl. cancer res
Asunto de la revista:
NEOPLASIAS
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Brasil