A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats
Biol. Res
; 49: 1-6, 2016. graf, tab
Article
en En
| LILACS
| ID: biblio-950842
Biblioteca responsable:
CL1.1
ABSTRACT
BACKGROUND:
It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HFD) could disturb the metabolism of glutamate and consequently the GABA levels, but the mechanism is not yet clearly understood. Therefore, the aim of this study was to investigate the effect of a HFD on the GABA levels in the FC and hippocampus of rats.RESULTS:
The HFD significantly increased weight gain and blood glucose levels, whereas decreased the GABA levels in the FC and hippocampus compared with standard diet-fed rats.CONCLUSIONS:
HFD decreases GABA levels in the FC and hippocampus of rat, which likely disrupts the GABAergic inhibitory processes, underlying feeding behavior.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
LILACS
Asunto principal:
Dieta Alta en Grasa
/
Lóbulo Frontal
/
Ácido gamma-Aminobutírico
/
Hipocampo
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
Biol. Res
Asunto de la revista:
BIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Chile