Multidisciplinary cancer care may impact on the postoperative mortality and survival of patients with oesophageal and oesophagogastric junction cancer: a retrospective cohort study
Clin. transl. oncol. (Print)
; 17(3): 247-256, mar. 2015. tab, ilus
Artículo
en Inglés
| IBECS
| ID: ibc-133313
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Background. Modern management of Oesophageal and oesophagogastric junction (OGJ) cancers requires a multidisciplinary approach, which was implemented at our health centre in 2005. This study aimed to assess the impact of this change on clinical outcomes. Methods. A retrospective cohort study was conducted, covering all patients treated for oesophageal and OGJ cancer at the cancer centre established by the Bellvitge University Hospital and Catalonian Institute of Oncology, over two time periods, i.e. 20002004 and 20052008. Descriptive and multivariate analyses were performed using survival at 1 and 3 years as dependent variables. Results. Between 1 January 2000 and 31 December 2008, 586 patients were included. Number of patients with unknown stage at diagnosis was significantly reduced. Preoperative strategies at the oesophageal location clearly increased in the recent period. A multidisciplinary approach resulted in a significant reduction in surgical mortality (11.8 vs. 2 %) in the period 20052008. Analysis restricted to patients undergoing surgery with curative intent indicated a significant increase in 1- and 3-year survival in the latter period (68.4 vs. 89.8 and 38.2 vs. 57.1 %, respectively). Multivariate analysis showed that variables associated with improved survival were age; tumour stage; radical intent of treatment (surgery and radical combined chemoradiotherapy); and therapeutic strategy. Conclusion. Better selection of patients for therapy together with improved staging resulted in a significant improvement in 1- and 3-year survival in cases undergoing surgery with curative intent. These changes would support the adoption of a multidisciplinary approach to clinical decision-making in cases of oesophageal and OGJ cancer (AU)
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Colección:
Bases de datos nacionales
/
España
Contexto en salud:
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
Problema de salud:
Enfermedades del Sistema Digestivo
/
Neoplasia Esofágica
Base de datos:
IBECS
Asunto principal:
Neoplasias Esofágicas
/
Unión Esofagogástrica
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Clin. transl. oncol. (Print)
Año:
2015
Tipo del documento:
Artículo
Institución/País de afiliación:
Bellvitge University Teaching Hospital/Spain
/
Catalonian Cancer Strategy/Spain
/
Catalonian Institute of Oncology/Spain