Epidemiology and pathophysiology of malignancy in common variable immunodeficiency?
Allergol. immunopatol
; 45(6): 602-615, nov.-dic. 2017. tab, graf
Article
en En
| IBECS
| ID: ibc-168469
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Common variable immunodeficiency (CVID) is a diagnostic category of primary immunodeficiency (PID) which may present with heterogeneous disorders including recurrent infections, autoimmunity, granulomatous diseases, lymphoid and other types of malignancies. Generally, the incidence of malignancy in CVID patients is around 1.5-20.7% and usually occurs during the 4th-6th decade of life. Non-Hodgkin lymphoma is the most frequent malignancy, followed by epithelial tumours of stomach, breast, bladder and cervix. The exact pathological mechanisms for cancer development in CVID are not fully determined; however, several mechanisms including impaired genetic stability, genetic predisposition, immune dysregulation, impaired clearance of oncogenic viruses and bacterial infections, and iatrogenic causes have been proposed to contribute to the high susceptibility of these patients to malignancies (AU)
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Inmunodeficiencia Variable Común
/
Linfoma
/
Neoplasias
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Allergol. immunopatol
Año:
2017
Tipo del documento:
Article