Pathology findings and clinical outcomes after risk reduction salpingo-oophorectomy in BRCA mutation carriers: a multicenter Spanish study
Clin. transl. oncol. (Print)
; 20(10): 1337-1344, oct. 2018. tab, graf
Artículo
en Inglés
| IBECS
| ID: ibc-173722
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Objective:
To determine the incidence of serous tubal intraepithelial carcinoma (STIC) after risk reduction salpingo-oophorectomy(RRSO), and to describe oncological outcomes after RRSO. Materials andmethods:
BRCA pathogenic mutation carriers who had undergone an RRSO were evaluated in this retrospective multicenter observational study. Patients were only included when fallopian tubes were analyzed following the protocol for Sectioning and Extensively Examining the FIMbria (SEE-FIM). Surgeries were performed between June 2010 and April 2017 at eight Spanish hospitals.Results:
A total of 359 patients met the inclusion criteria. STIC was diagnosed in 3 (0.8%) patients; one of them underwent surgical staging due to positive peritoneal washing, with absence of disease at the final pathology report. None of the three patients received adjuvant chemotherapy and were free of disease at last follow-up. Fallopian tube and ovarian carcinoma were diagnosed in 5 (1.4%) and 1 (0.3%), respectively. At a median (range) follow-up time of 29 (3-92) months, five patients had a newly diagnosed breast cancer. Other types of cancer, which were diagnosed during the follow-up time, included serous primary peritoneal carcinoma (n = 1), serous endometrial carcinoma (n = 1), colon (n = 1), pancreas (n = 1), jaw (n = 1), and lymphoma (n = 1). Seven patients died due to different types of cancer breast (n = 4), pancreas (n = 1), jaw (n = 1), and colon (n = 1).Conclusion:
The incidence of STIC after RRSO in BRCA mutation carriers is low (0.8%) and it presents an excellent oncological outcome. Patients after RRSO, however, run the risk to develop other types of cancer during follow-up and should be properly advised before the prophylactic surgeryRESUMEN
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Colección:
Bases de datos nacionales
/
España
Contexto en salud:
Agenda de Salud Sostenible para las Américas
/
ODS3 - Salud y Bienestar
Problema de salud:
Objetivo 9: Enfermedades no transmisibles y salud mental
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Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles
Base de datos:
IBECS
Asunto principal:
Neoplasias Ováricas
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Ovariectomía
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Genes BRCA1
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Salpingectomía
Tipo de estudio:
Ensayo clínico controlado
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Estudio diagnóstico
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Estudio de etiología
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Guía de práctica clínica
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Estudio observacional
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Factores de riesgo
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Clin. transl. oncol. (Print)
Año:
2018
Tipo del documento:
Artículo
Institución/País de afiliación:
CEU San Pablo University/Spain
/
Complejo Hospitalario Universitario Insular Materno-Infantil de Canarias (CHUIMI)/Spain
/
Hospital Italiano de Buenos Aires/Argentina
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Hospital Universitario 12 de Octubre/Spain
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Hospital Universitario Príncipe de Asturias de Alcalá de Henares/Spain
/
Hospital Universitario Quirón/Spain
/
Hospital Universitario Reina Sofía/Spain
/
Hospital Universitario Vall d'Hebron/Spain
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Hospital Universitario de Getafe/Spain
/
Instituto Valenciano de Oncología (IVO)/Spain