IgE-mediated sensitization to galactose-alfa-1.3-galactose (alfa-Gal) in urticaria and anaphylaxis in Spain: geographical variations and risk factors
J. investig. allergol. clin. immunol
; 29(6): 436-443, 2019. tab, graf
Article
en En
| IBECS
| ID: ibc-189780
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
BACKGROUND:
The objectives of this study were to investigate the prevalence of sIgE to galactose-alfa-1,3-galactose (alfa-gal) in individuals with acute urticaria or anaphylaxis from different geographical areas of Spain and to evaluate the relevance of demographics and lifestyle as risk factors for this immune response.METHODS:
Participants were recruited from allergy departments at 14 Spanish hospitals. Patients aged 18 years or older presenting with urticaria or anaphylaxis were enrolled into one of 2 arms cases and controls. An interviewer-administered questionnaire collecting demographic data, lifestyle habits, and the presence of cofactors was obtained from each participant. sIgE to alfa-gal and total IgE were determined using ImmunoCAP. sIgE levels ≥0.35 kU/L were considered a positive result.RESULTS:
The study population comprised 160 cases and 126 controls. The median age was 44 years. The overall prevalence of a positive result of sIgE to alfa-gal was 15.7%; this was higher in cases (26.3%) than in controls (2.4%). The sIgE anti-alfa-gal positivity rate ranged from 37.68% (rural) to 15.38% (semiurban), and 7.85% (urban). The rates of positivity were 46.32%, (Northern), 0.72% (Center), and 0% (Mediterranean). A positive result for sIgE to alfa-gal was associated with a history of tick bites, participation in outdoor activities, pet ownership, and ingestion of mammalian meats or innards before the onset of symptoms. Only alcohol consumption could be implicated as a cofactor.CONCLUSION:
Sensitization to alfa-gal in patients with urticaria or anaphylaxis differs considerably between the 3 geographical areas studied and is related to tick bites
Texto completo:
1
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Urticaria
/
Inmunoglobulina E
/
Alérgenos
/
Enfermedades por Picaduras de Garrapatas
/
Disacáridos
/
Hipersensibilidad
/
Anafilaxia
Límite:
Adult
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Female
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Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
J. investig. allergol. clin. immunol
Año:
2019
Tipo del documento:
Article