Atezolizumab in locally advanced or metastatic urothelial cancer: a pooled analysis from the Spanish patients of the IMvigor 210 cohort 2 and 211 studies
Clin. transl. oncol. (Print)
; 23(4): 882-891, abr. 2021. graf
Artículo
en Inglés
| IBECS
| ID: ibc-220925
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Background The studies IMvigor 210 cohort 2 and IMvigor211 evaluated the efficacy of atezolizumab in patients with locally advanced or metastatic urothelial cancer (mUC) upon progression to platinum-based chemotherapy worldwide. Yet, the real impact of this drug in specific geographical regions is unknown. Materials and methods We combined individual-level data from the 131 patients recruited in Spain from IMvigor210 cohort 2 and IMvigor211 in a pooled analysis. Efficacy and safety outcomes were assessed in the overall study population and according to PD-L1 expression on tumour-infiltrating immune cells. Results Full data were available for 127 patients; 74 (58%) received atezolizumab and 53 (42%) chemotherapy. Atezolizumab patients had a numerically superior median overall survival although not reaching statistical significance (9.2 months vs 7.7 months). No statistically significant differences between arms were observed in overall response rates (20.3% vs 37.0%) or progression-free survival (2.1 months vs 5.3 months). Nonetheless, median duration of response was superior for the immunotherapy arm (non-reached vs 6.4 months; p = 0.005). Additionally, among the responders, the 12-month survival rates seemed to favour atezolizumab (66.7% vs 19.9%). When efficacy was analyzed based on PD-L1 expression status, no significant differences were found. Treatment-related adverse events of any grade occurred more frequently in the chemotherapy arm [46/57 (81%) vs 44/74 (59%)]. Conclusion Patients who achieved an objective response on atezolizumab presented a longer median duration of response and numerically superior 12 month survival rates when compared with chemotherapy responders along with a more favorable safety profile. PD-L1 expression did not discriminate patients who might benefit from atezolizumab (AU)
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
España
Base de datos:
IBECS
Asunto principal:
Neoplasias Ureterales
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Carcinoma de Células Transicionales
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Anticuerpos Monoclonales Humanizados
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Antineoplásicos
Límite:
Adulto
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Anciano
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Femenino
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Humanos
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Masculino
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Clin. transl. oncol. (Print)
Año:
2021
Tipo del documento:
Artículo
Institución/País de afiliación:
CIBERONC/Spain
/
Doce de Octubre University Hospital/Spain
/
Marqués de Valdecilla University Hospital/Spain
/
Ramon y Cajal University Hospital/Spain
/
Roche Farma S.A/Spain
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Universitat Autònoma de Barcelona/Spain
/
University Clinic of Navarra/Spain
/
Vall dHebron University Hospital/Spain