Validation of the CoVID-TE model as a tool to predict thrombosis, bleeding, and mortality in the oncology patient with Sars-Cov-2 infection: a study by the SEOM cancer and thrombosis group
Clin. transl. oncol. (Print)
; 26(1): 171-177, jan. 2024. tab, graf
Article
en En
| IBECS
| ID: ibc-229155
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Purpose The CoVID-TE model was developed with the aim of predicting venous thrombotic events (VTE) in cancer patients with Sars-Cov-2 infection. Moreover, it was capable of predicting hemorrhage and mortality 30 days following infection diagnosis. The model is pending validation. Methods/patients Multicenter retrospective study (10 centers). Adult patients with active oncologic disease/ antineoplastic therapy with Sars-Cov-2 infection hospitalized between March 1, 2020 and March 1. 2022 were recruited. The primary endpoint was to study the association between the risk categories of the CoVID-TE model and the occurrence of thrombosis using the Chi-Square test. Secondary endpoints were to demonstrate the association between these categories and the occurrence of post-diagnostic Sars-Cov-2 bleeding/ death events. The KaplanMeier method was also used to compare mortality by stratification. Results 263 patients were enrolled. 59.3% were men with a median age of 67 years. 73.8% had stage IV disease and lung cancer was the most prevalent tumor (24%). A total of 86.7% had an ECOG 02 and 77.9% were receiving active antineoplastic therapy. After a median follow-up of 6.83 months, the incidence of VTE, bleeding, and death 90 days after Sars-Cov-2 diagnosis in the low-risk group was 3.9% (95% CI 1.97.9), 4.5% (95% CI 2.38.6), and 52.5% (95% CI 45.259.7), respectively. For the high-risk group it was 6% (95% CI 2.613.2), 9.6% (95% CI 5.017.9), and 58.0% (95% CI 45.366.1). The Chi-square test for trends detected no statistically significant association between these variables (p > 0.05). Median survival in the low-risk group was 10.15 months (95% CI 3.8416.46), while in the high-risk group it was 3.68 months (95% CI 0.07.79). The differences detected were not statistically significant (p = 0.375) (AU)
Palabras clave
Texto completo:
1
Colección:
06-national
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ES
Base de datos:
IBECS
Asunto principal:
Tromboembolia
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Trombosis
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Neoplasias
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Clin. transl. oncol. (Print)
Año:
2024
Tipo del documento:
Article