Efficacy of high-dose sublingual immunotherapy in children allergic to house dust mites in real-life clinical practice
Allergol. immunopatol
; 39(3): 122-127, mayo-jun. 2011. tab, graf
Article
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| IBECS
| ID: ibc-90098
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Background: The aim of the study was to evaluate the efficacy and safety of high-dose mite sublingual immunotherapy (SLIT) administered in children with allergic rhinitis in real-life clinical practice. More over, we analysed the clinical course of asthma severity. Methods: Retrospective, observational, monocentre study. Medical records of patients treated between 2001 and 2008 were reviewed. Patients received a standardised Dermatophagoide spteronyssinus + Dermatophagoides farinae extract (300 IR/ml) manufactured by Stallergenes (Staloral® 300). Patients were evaluated before SLIT initiation and at 6, 12, 24, 36 and 48 months. Global assessment of SLIT efficacy was measured using a visual analogue scale (VAS) and a rhinitis medication consumption score (RMCS). A global asthma score was used to estimatethe clinical course of asthma severity. Results: We obtained data from 78 patients, 43.6% male. The mean (±SD) age was 11.0 ± 3.0 years. Most patients (69.2%) suffered from allergic rhinitis plus asthma. Patient evaluation of allergy severity (VAS) revealed a highly significant improvement between baseline and six months (p<0.001, Wilcoxon test): 4.0 ± 1.7 cm vs. 7.3 ± 4.6 cm. This improvement was maintained throughout the four-year follow-up period. The use of medications (RMCS) was significantly reduced in the first six months (4.6±2.5 points at baseline vs. 0.8±1.6 points atsix months visit, p<0.001, Wilcoxon test) and remained very low until the end of follow-up. We did not find a temporal improvement in asthma severity. Conclusions: This retrospective study indicates that high-dose SLIT in children with rhinitis caused by house dust mites is well-tolerated and could be an effective treatment (AU)
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Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Asma
/
Rinitis Alérgica Perenne
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Desensibilización Inmunológica
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Antígenos Dermatofagoides
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Allergol. immunopatol
Año:
2011
Tipo del documento:
Article