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TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma
Freitas Silva, Brunno-Santos de; Yamamoto, Fernanda-Paula; Corrêa Pontes, Flávia-Sirotheau; Antonio-Rebelo Pontes , Hélder; Elias-Vieira Cury, Sérgio; Fonseca, Felipe-Paiva; Santos Pinto-Júnior, Décio-dos.
Afiliación
  • Freitas Silva, Brunno-Santos de; University of São Paulo. Dental School. Department of Oral Pathology. São Paulo. Brazil
  • Yamamoto, Fernanda-Paula; University of São Paulo. Dental School. Department of Oral Pathology. São Paulo. Brazil
  • Corrêa Pontes, Flávia-Sirotheau; Federal University of Pará. Dental School. Department of Oral Pathology. s. c. Brazil
  • Antonio-Rebelo Pontes , Hélder; Federal University of Pará. Dental School. Department of Oral Pathology. s. c. Brazil
  • Elias-Vieira Cury, Sérgio; UNIFOA. Dental School. Department of Stomatology. Rio de Janeiro. Brazil
  • Fonseca, Felipe-Paiva; Piracicaba-UNICAMP. Dental School. Department of Oral Pathology. São Paulo. Brazil
  • Santos Pinto-Júnior, Décio-dos; University of Sao Paulo. Dental School. Department of Oral Pathology. São Paulo. Brazil
Med. oral patol. oral cir. bucal (Internet) ; 17(1): 29-34, ene. 2012. ilus
Article en En | IBECS | ID: ibc-98913
Biblioteca responsable: ES1.1
Ubicación: BNCS
ABSTRACT

Objectives:

The aim of this study was to evaluate the immunoexpression of TWIST and p-Akt proteins in oralleukoplakia (OL) and oral squamous cell carcinoma (OSCC), correlating their expressions with the histological features of the lesions. Study

design:

Immunohistochemical studies were carried out on 10 normal oral epithelium, 30 OL and 20 OSCC formalin-fixed, paraffin-embedded tissue samples. Immunoperoxidase reactions for TWIST and p-Akt proteins were applied on the specimens and the positivity of the reactions was calculated for 1000 epithelial cells.

Results:

Kruskal-Wallis and Dunn’s post tests revealed a significant difference in TWIST and p-Akt immune expression among normal oral mucosa, OL and OSCC. In addition, a significant positive correlation was found between TWIST and p-Akt expressions according to the Pearson’s correlation test.

Conclusions:

The results obtained in the current study suggest that TWIST and p-Akt may participate of the multistep process of oral carcinogenesis since its early stages (AU)
Asunto(s)
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Colección: 06-national / ES Base de datos: IBECS Asunto principal: Leucoplasia Bucal / Neoplasias de la Boca / Proteína Oncogénica v-akt / Proteína 1 Relacionada con Twist Límite: Humans Idioma: En Revista: Med. oral patol. oral cir. bucal (Internet) Año: 2012 Tipo del documento: Article
Buscar en Google
Colección: 06-national / ES Base de datos: IBECS Asunto principal: Leucoplasia Bucal / Neoplasias de la Boca / Proteína Oncogénica v-akt / Proteína 1 Relacionada con Twist Límite: Humans Idioma: En Revista: Med. oral patol. oral cir. bucal (Internet) Año: 2012 Tipo del documento: Article