High fat diet-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signalling
J. physiol. biochem
; 80(1): 113-126, Feb. 2024. ilus, graf
Article
en En
| IBECS
| ID: ibc-EMG-570
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
The global prevalence and incidence of non-alcoholic fatty liver disease (NAFLD) are exhibiting an increasing trend. NAFLD is characterized by a significant accumulation of lipids, though its underlying mechanism is still unknown. Here we report that high-fat diet (HFD) feeding induced hepatic steatosis in mice, which was accompanied by a reduction in the expression and function of hepatic TRPV2. Moreover, conditional knockout of TRPV2 in hepatocytes exacerbated HFD-induced hepatic steatosis. In an in vitro model of NAFLD, TRPV2 regulated lipid accumulation in HepG2 cells, and TRPV2 activation inhibited the expression of the cellular senescence markers p21 and p16, all of which were mediated by AMPK phosphorylation. Finally, we found that administration of probenecid, a TRPV2 agonist, impaired HFD-induced hepatic steatosis and suppressed HFD-induced elevation in p21 and p16. Collectively, our findings imply that hepatic TRPV2 protects against the accumulation of lipids by modulating p21 signalling. (AU)
Palabras clave
Buscar en Google
Texto completo:
1
Colección:
06-national
/
ES
Base de datos:
IBECS
Asunto principal:
Hígado Graso
/
Dieta Alta en Grasa
/
Enfermedad del Hígado Graso no Alcohólico
/
Insuficiencia Respiratoria
/
Infecciones del Sistema Respiratorio
/
Células Sanguíneas
/
Composición Corporal
/
Médula Ósea
/
Linfocitos T
/
Absorciometría de Fotón
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Female
/
Male
/
Adolescent
/
Adult
/
Aged
/
Child
Idioma:
En
/
Es
Revista:
Arch. bronconeumol. (Ed. impr.)
/
J. physiol. biochem
/
An. pediatr. (2003. Ed. impr.)
/
Nutr. hosp
Año:
2023
/
2022
/
2024
Tipo del documento:
Article