The effect of tubero-infundibular dopaminergic neurons on prolactin and alpha-melanocyte stimulating hormone release
Braz. j. med. biol. res
; 24(10): 1059-62, 1991. ilus
Artículo
en Inglés
| LILACS
| ID: lil-102089
Biblioteca responsable:
BR1.1
ABSTRACT
The effect of tubero-infundibular dopaminergic neurons (TIDA) on the release of prolactin (PRL) and alpha-melanocyte stimulating hormone (alpha-MSH) was studied in median eminence-lesioned (MEL) male rats (N = 6-28). Plasma PRL and alpha-MSH levels were significantly elevated 2(86.1 ñ 19.8 and 505.1 ñ 19.1 ng/ml), 4(278.7 ñ 15.5 and 487.4 ñ 125.1 ng/ml), 7 (116.2 ñ 16.2 and 495.8 ñ 62.6 ng/ml) and 14 (247.3 ñ 26.1 and 448.4 ñ 63.8 ng/ml) days after MEL when compared to sham-operated control animals (55.5 ñ 13.4 and 56.2 ñ 6.1 ng/ml, repectively). MEL altered plasma PRL and alpha-MSH levels in a diffential manner, with 1.5-to5.0-fold increase in PRL and an 8.0- to 9.0-fold increase in alpha-MSH. The increase of alpha-MSH levels occured abruptly and remained constant from days 2 to 14. These observations indicate that TIDA plays an important role in the pituitary release of PRL and alpha-MSH and provide evidence that the release of the two hormones occurs in a differential manner
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Colección:
Bases de datos internacionales
Base de datos:
LILACS
Asunto principal:
Prolactina
/
Alfa-MSH
/
Eminencia Media
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1991
Tipo del documento:
Artículo
/
Congreso y conferencia
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Documento de proyecto