Production of an effective anti-Bothrops-tetanus mixed hyperimmune serum of equine origin
J. venom. anim. toxins
; 4(1): 70-8, 1998. tab
Artículo
en Inglés
| LILACS
| ID: lil-201616
Biblioteca responsable:
BR33.1
RESUMO
The present investigation reveals the possibility of simultaneous immunization of horses with Bothrops or Crotalus snake venoms and Tetanus antigens for the production of anti-Bothrops-Tetanus or anti-Crotalus-Tetanus mixed serum, with high titers of the respective specific antibodies. Bothrops antivenoms with an average neutralizing titer of 4.16 mg venom/ml were obtained from plasma of horses with titers lower than 0.5 mg venom/ml when Tetanus antigens were not used. This suggests the existence of a synergism between Bothrops venoms and Tetanus antigens in the stimulation of the antibody response. The pooled plasma of the animal had a neutralizing titer of 21.0 mg/ml reference Bothrops venoms and 3,300 IU/ml to Tetanus antigens after purification by enzymatic digestion and ammonium sulphate precipitation. These experiments lead us to conclude that Bothrops envenomation therapy can be successfully performed using Anti-Bothrops-Tetanus serum also serving as Tetanus prophylaxis. anti-Crotalus-Tetanus serum can also be produced, although it is not of medical interest as Crotalus envenomation rarely results in local necrotizing lesions.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Contexto en salud:
ODS3 - Salud y Bienestar
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Base de datos:
LILACS
Asunto principal:
Venenos de Serpiente
/
Tétanos
/
Antivenenos
/
Inmunización
/
Clostridium tetani
/
Caballos
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins
Asunto de la revista:
Toxicología
Año:
1998
Tipo del documento:
Artículo